Showing posts with label Hiv. Show all posts
Showing posts with label Hiv. Show all posts

Thursday, 23 August 2012

Neutralizing Antibodies-Protective Immunity-HIV

HIV Protection Without Circulating Blood Antibodies

Biomed Middle East: "New research shows that protective immunity against HIV can be achieved without the presence of virus neutralizing antibodies in the blood. The study, published by Cell Press in the February issue of the journal Immunity, demonstrates that a vaccine which stimulates production of specific anti-HIV antibodies in the vaginal tissue was sufficient to protect monkeys from exposure to live virus. The results may also help to explain why a few individuals who lack anti-HIV antibodies in the blood are able to resist infection, even when they are repeatedly exposed to HIV. ..."We may have been able to recapitulate in a vaccine what a few individuals do naturally." read more..

Friday, 20 July 2012

Transmission Of Hiv-Male Circumcision-HIV

Get Circumcised or Get Labeled

My first big shock when I started to follow HIV related issues in East Africa was that it was assumed almost all Transmission was sexual in Africa (though nowhere else). Then, to 'work out' how this could possibly generate such massive epidemics, there was also the tendency to go from the number infected, or said to be infected, to the absurdly high levels of unsafe sexual behavior that would be needed to explain high levels of heterosexual transmission of HIV. There has never been any evidence that unsafe heterosexual sex alone could explain Africa's worst HIV epidemics. But all the 'work' to prevent infection appeared to concentrate on sexual transmission.
If not all HIV is transmitted sexually, many interventions that target sexual behavior, whether levels are real or assumed, will fail. Abstinence and other associated campaigns didn't even sound plausible before they were implemented, but enormous amounts of money was ploughed into them. Some equally dubious interventions were dreamed up and most probably also had little positive effect; as for any negative effects, these are unlikely to have been measured, let alone alluded to in the copious self-congratulatory literature that has emerged from what became the extremely lucrative HIV industry.
When circumcision was mooted as a possible intervention, it seemed to suffer from the above problem; it would, at best, protect against heterosexual transmission; it would not protect men who have sex with men, infants who are infected by their mothers or intravenous drug users. Indeed, it turned out that it wouldn't protect women either, and probably increases transmission from men to women. It will not reduce non-sexual transmission of any kind, including that through unsafe healthcare or cosmetic practices. Worse, in the sub-standard health facilities that ordinary Africans are forced to use, mass male circumcision programs might add to the problem, with men being infected in the health facility where the operation is carried out.
But those receiving circumcision related funding continue to insist on the effectiveness of such programs, shouting down any opposition, churning out figures which could be interpreted to show that male circumcision reduce transmission from women to men, but never actually engaging with the opposition. There are now so many problems with male circumcision as a strategy that the whole exercise to circumcise between 22 and 38 million African men should be suspended. There is so much disinformation and consequent misunderstanding that the campaign is unlikely to do any good and is in serious danger of doing a lot of harm. At best, it is just another neo-colonial excess of the kind that probably ensured that HIV would become the pandemic that it now is.
Kenya's Nairobi Star is currently doing a great job adding to the obfuscation that seems to pass for scientific journalism. The article 'Study Claiming Cut Does Not Inhibit HIV Rejected' makes a shaky start by incorrectly suggesting the study was not published or that its findings were refuted, or were even addressed by those promoting circumcision. The cited claims from the study are, in fact, correct, but they are only the tip of the iceberg. Interviewing those who would have a lot to lose if the circumcision program was suspended and asking their opinion is easy enough. But is it adequate journalism? Does the public really need more of the selective use of factoids to justify spending hundreds of millions of dollars on a campaign that is likely to be of so little benefit (at best)?
Other countries have less to say about the latest paper, one of several that has managed to get through the HIV industry's censorship process (peer review). Uganda's press has commented on circumcision from time to time, but only to beat the orthodox drum. It is claimed that 600,000 men have already been circumcised under the program since 2009, but it is unclear where this figure comes from. Natu read more..

Monday, 9 July 2012

Rakai, Uganda-Circumcision-Implications

Wait and wipe, don’t cut

Last week, while looking for something else, I ran across a report that has big Implications for HIV/AIDS prevention in Africa: Almost five years ago, a trial of Circumcision to protect men in Rakai, Uganda, reported that intact (uncircumcised) men who waited at least 10 minutes after sex before cleaning their penis were at less risk [...] read more..

Sunday, 17 June 2012

Government Officials-Civil Society Groups-Bangkok, Thailand-Statute Books-HIV

Stop Using Laws as Weapons Against HIV Prevention

Open Society Foundations Blog: "These stories stand beside countless others as testament that what is written in the statute books, and what is done by governments and others in the name of the law, can significantly increase the vulnerability of groups that are already at a high risk of HIV and other serious diseases. This week in Bangkok, Thailand, civil society groups that represent sex workers, drug users, men who have sex with men, people living with HIV, women and children, and those seeking access to essential medicines, will sit down with government officials and policymakers from across the Asia-Pacific region to share their experiences of how the law affects their daily lives." read more..

Thursday, 14 June 2012

Child Hiv Transmission-African Countries-Sexual Behavior-Hiv Prevalence

City Dwellers Are From Mars, Rural Dwellers Are From Venus, Or Something Like That

Despite the monstrous quantities of 'unsafe' sex that Africans are claimed to engage in by UNAIDS and other HIV institutions, HIV is not at all distributed evenly. Prevalence ranges from less than 1% in some African countries, a lot less than in some US cities, to more than 25% of the adult population in others (and even 50% in some demographic groups). Even within high prevalence countries HIV is not distributed evenly. In many African countries the virus tends to be far more common in cities, close to main roads, close to health facilities, among wealthier and better educated people, etc. It is also generally far more common among women than among men.
Other research has found HIV prevalence to be higher in areas where diseases such as schistosomiasis (bilharzia) and malaria are higher. However, as these both tend to be higher among less wealthy people with lower levels of education and in rural, as opposed to urban areas, there is more than a suggestion that HIV transmission may have widely varying risk factors. Yet UNAIDS and friends tend not to dwell on most forms of non-sexual risk in Africa.
As David Gisselquist writes in the Don't Get Stuck With HIV website: "Unlike Western countries, where almost all HIV transmission occurs outside families, a lot of HIV transmission in Africa happens within families – mother-to-child and spouse-to-spouse transmission together account for an estimated 45% of new infections." Not only is a lot of HIV not transmitted sexually, but a lot is not transmitted through 'unsafe' sex. Many of these couples where at least one partner is infected have no sexual risks. Hundreds of thousands of new infections every year occur through these two routes.
In Africa, then, the main groups are those at risk of mother to child transmission and married couples, especially couples where one partner has been infected. It's as likely to be the female as the male partner, but how does the index partner become infected, the first in the couple? Sex, says UNAIDS, but sex with whom, how much sex and what kind of sex? Heterosexual sex is not an efficient means of transmitting HIV. Gisselquist is suggesting that the focus of international HIV reduction efforts in African countries should address these and other risk groups, where sexual risk is very likely to be low but HIV prevalence is high; this could cut as many as 700,000 transmissions annually.
A serious set of risk factors could arise from unsafe healthcare and perhaps even unsafe cosmetic services. It's not just that conditions in healthcare and cosmetic facilities in African countries are primitive but also that many people are not aware that such risks exist; if they are not aware of the risks, they will not know that they need to avoid them, nor how to avoid them. But if they are aware, they will also realize that a person's HIV status is not a reliable indication of their sexual behavior. This should reassure some who have been brainwashed to associate HIV with 'immoral' behavior; many women, especially, have been beaten by their partners, ostracized by their communities and even killed because of the incorrect association of HIV with sexual behavior.
The HIV industry does talk a lot about the importance of HIV testing. But they also put people off testing where being positive has such terrible consequences. If people were to know that there were other, non-sexual risks, the stigma associated with testing and with having (or being thought to have) HIV should reduce. People who know their status don't tend to take risks, neither sexual nor non-sexual; but they must also be advised of the non-sexual risks. Those who are infected non-sexually can be involved in sexual transmission just as easily as those who are infected sexually. But in the current climate of sex-obsessed HIV policies, they are unlikely to know about non-sexual risk.
Prevention of mother to child HIV transmission is vital if the mother is already infec read more..

Wednesday, 6 June 2012

Success Story-Social Change-Zimbabwe-HIV

Learn From Zim How To Fight HIV/AIDS

RadioVop Zimbabwe: "'The modelling showed it couldn't just be the natural curve [of the epidemic]; the decline was too dramatic,' he told IRIN/PlusNews. 'The modelling suggested it was also due to behaviour change and behavioural data also suggested a change, but what was missing was the all important `why'.' According to Halperin, Zimbabwe's success story points to the power of social change and the need for more detailed analyses of HIV success stories in Africa. He compared it to the role of partner reduction in the fight against HIV in Uganda, which promoted a reduction in concurrent partners as the key focus of its HIV prevention campaigns in the late 1980s and early 1990s." read more..

Tuesday, 5 June 2012

Transmission Of Hiv-Joseph Sonnabend

Have we ignored a very simple procedure that could significantly reduce the risk of sexual transmission of HIV to men from women?

This was written together with Joseph Sonnabend In 2010 there was a great deal of outraged comment about the US government’s award of $823,000 to an HIV related project in Africa. Specifically, the taxpayer dollars were to be used to teach uncircumcised African men how to wash their genitals after having sex. The grant states; [...] read more..

Monday, 4 June 2012

Voluntary Counseling And Testing-Religious Leaders-Hiv Prevention

SAVE families, stop HIV!

The International (formerly African) Network of Religious Leaders living with or Affected by HIV/AIDS (INERELA+) promotes SAVE as a response to Africa’s HIV/AIDS epidemic. SAVE stands for: Safe sexual and skin-piercing behavior; Access to treatment; Voluntary counseling and testing; and Empowerment. This note considers some of the ways that SAVE could strengthen Hiv Prevention in Africa. AIDS was first recognized [...] read more..

Retraction: 127 Zimbabwean Women-Antiretroviral Drug-HIV

RETRACTION: 127 Zimbabwean Women Were Not Infected With HIV During Trial

Following an article in ZimEye.org, I mistakenly wrote that one arm of the Vaginal and Oral Interventions to Control the Epidemic (VOICE) trial, involving the antiretroviral drug Tenofovir, was stopped because 127 women taking the drug became infected with HIV. In fact, these women were taken out of the trial because of 'futility', the finding that it would not be possible to show that the treatment they were receiving was more effective than the placebo that another group was receiving.I apologise for reporting something so alarmist when the only source was an online article (which apparently also appeared in the Sunday Mail) that was released without any named author. I will take more care in commenting on such articles in the future. I have removed my blog post from the three sites where I placed it and will make the same efforts to publicize this retraction as I made with the original.There will be a press release confirming the above, which I will post as a comment to this report as soon as it is available.Pre-exposure prophylaxis (PrEP) involves putting HIV negative people on antiretroviral drugs (ARV) with the aim of protecting them from HIV infection. read more..

Friday, 25 May 2012

The World Health Organization-Outbreak Investigations-Health Care-HIV

Outbreak investigations: Facing and fixing problems

If a hospital or clinic infects you or your child with HIV, you’d probably call it a disaster. Health care bureaucrats and managers call it an “adverse event.”  How often do patients get HIV from health care in Africa? The World Health Organization (WHO) has estimated it happens 50,000-100,000 times each year.  Other estimates are higher. That’s [...] read more..

Sunday, 20 May 2012

Unsafe Injections-North America

Lessons from North American outbreaks – changing needles alone is not enough

[go to first injections page] [Note: Stephen F. Minkin (sfminkin@yahoo.com) submitted the following as a guest blog. Unsafe injections are a problem in North America as well, but not nearly as much as in Africa and Asia. When unexplained infections come to light, and when these can be traced to suspected clinics, state or national governments in North [...] read more..

Saturday, 19 May 2012

Pre-Exposure Prophylaxis-African Countries-Hiv Negative-HIV

Experts Unambiguously Opposed to Saying the Wrong Thing

Apologies for the lack of posting this year but I have had enough work keeping my other blog going. The subject of PrEP and related issues do also crop up there, though.
Daily use of Truvada has been backed for pre-exposure prophylaxis use by a panel of 'experts', which generally refers to people who are so well paid to say the right thing that no one else will disagree with them. It's likely that this use of the drug will soon be approved by the FDA. I wasn't able to find a register of the 'experts'' interests but I'm sure it would make interesting reading.
If approved, the drug will be prescribed for HIV negative people who are thought to be at high risk of being infected sexually, which generally refers to men who have sex with men in Western countries. The drug is not being considered for use by intravenous drug users. It is also unlikely to be of much value for commercial sex workers in wealthy countries as they are rarely infected unless they are also intravenous drug users or face other serious risks.
This suggests that PrEP is unlikely to be effective in high HIV prevalence developing countries, where high risk groups are not easy to identify. In many African countries, the bulk of infections among adults occur in married people and those in long term relationships, who don't face very high sexual risks. In other words, the drug is of little use as PrEP where it is most needed. But I'm sure that won't stop Big Pharma from lobbying the right people so that the potential tens or hundreds of millions of Africans can be exploited.
The process of palming off useless but extremely expensive drugs with potentially dangerous side-effects on Africans has been eased by years of publicity for the dominant HIV transmission paradigm, which says that almost all HIV in African countries is transmitted through heterosexual behavior. The fact that the paradigm is seriously challenged by empirical data has done little to influence policy, which concentrates on the politician, religious leader and media friendly process of wagging fingers, pointing fingers and poking fingers into the many HIV fuding pies.
Opposition from groups who claim to represent the interests of HIV positive people has almost all been taken care of in the time honored fashion of paying off anyone who speaks out of turn (or rubbishing anyone who won't take payment). A rare voice of dissent comes from the Aids Healthcare Foundation, which has consistently opposed the current trend of rushing into practices which have little empirical backing, but which mysteriously receive full backing from 'experts'.
Pharmaceutical front group Aids Vaccine Advocacy Coalition (AVAC), predictably, blow the trumpet for PrEP; pharmaceutical products ostensibly produced to treat illness would never have become as profitable if they were only used by sick people. But the UK's Nick Partridge puts his finger on the problem, probably inadvertently: "But we need to know if people at highest risk of infection are prepared to take a pill every day and whether there would be an increase in risk-taking behaviour which could outweigh the prevention effectiveness of Truvada."
The truth is, we don't know who is at highest risk in high prevalence countries, we know that most will not take the pill every day and it's very likely there will be an increase in risk-taking behavior, especially where people opt for PrEP because they know (or even think) they are at risk.
[For more about non-sexual HIV transmission and male circumcision, see the Don't Get Stuck With HIV site.]Pre-exposure prophylaxis (PrEP) involves putting HIV negative people on antiretroviral drugs (ARV) with the aim of protecting them from HIV infection. read more..

Friday, 27 April 2012

Hiv Persistence-Hiv Functional-Hiv Research-HIV

Dr. Robert C Gallo Interview: HIV Research at a Crossroad?

hiv-reservoir.net (Jan. 13, 2011): "Alain Lafeuillade: it looks like the terms ‘HIV sterilizing cure’ and ‘HIV functional cure’ are no longer ‘dirty’ words for scientists. What is the main gap in our knowledge about HIV persistence that should be resolved before we can envision new strategies to reach these goals?"Robert C. Gallo:  The answer is clearly demonstrating the precise cell types that are the source of persisting HIV.  This means cells that go beyond the common memory T cells that currently are chiefly studied, and demonstrating that by so-called “purging” these cells by activation mechanisms will lead to death of these cells.  At the moment this is the assumption." read more..

Thursday, 5 April 2012

Aids Healthcare Foundation-Yeghiayan Friedman-Ahf

By Lori Yeghiayan FriedmanAIDS Healthcare Foundation recently...

By Lori Yeghiayan FriedmanAIDS Healthcare Foundation recently brought its expert brand of HIV/AIDS services to the people of the deep South when one of its AHF “Magic Johnson” mobile testing units arrived on the steps of the Capitol in Jackson, Mississippi.
The services showcased by AHF were just a preview of coming attractions. Within the year, AHF will open an AHF Healthcare Center, as well as an AHF Pharmacy and HIV testing facility in Jackson. In addition, the group—the largest global AIDS organization—will operate a mobile unit, serving Jackson and the surrounding areas, in order to provide services to hard to reach populations.More info on this story at www.aidshealth.org. read more..

Saturday, 24 March 2012

Milton Hershey School-Boarding School-Hershey Candy

By Lori Yeghiayan FriedmanA Hershey-funded boarding school...

By Lori Yeghiayan FriedmanA Hershey-funded boarding school REJECTED an HIV-positive 13-year-old boy for admission, calling his status a “direct threat to the health & safety of others.”The young man is extremely disappointed in the decision and merely wants the opportunity to live his dreams, work hard and go to college.  In an interview with Poz Magazine, he said: “I used to look at Hershey as if I was already one of them. I just knew I would get in because I take pride in everything I do and I keep good grades. I have nothing wrong with me, and everyone that I know, who knows me, likes me.”AIDS Healthcare Foundation, the largest global AIDS organization, is calling for a BOYCOTT of all Hershey candy. We are asking people not to buy any Hershey candy until the company speaks out against AIDS discrimination at the Milton Hershey School and facilitates the boy’s enrollment at the school. Send a message to Hershey that AIDS discrimination is NOT acceptable.Sign the petition at: http://www.change.org/petitions/no-kisses-for-hershey-end-hiv-stigma read more..

Tuesday, 20 March 2012

Hiv Positive-HIV Patients-Prevention

Treatment As Prevention: Dream or Nightmare?

In the light of current enthusiasm for 'treatment as Prevention (or 'is' prevention or some other permutation)', it's sobering to read an article from the US entitled 'Only 28% of HIV patients have condition under control'. The idea of treatment as prevention, sometimes referred to as 'test and treat', is that it will be feasible to test about 80% of an entire population, not just once in a while, but regularly, perhaps once a year or more. Upon being found Hiv Positive people will receive immediate treatment, regardless of clinical stage.The US spends over $7,000 per capita according to WHO estimates for 2009; that's over 15% of GDP. Tanzania, in contrast, spends $57 per capita, 4.5% of GDP. So if only 28% of HIV positive people in the US are rendered unlikely to transmit the virus to others through having a low viral load, at least through (safe heterosexual) sex, and about 20% of those infected don't even know they are positive, where does this leave countries like Tanzania?Figures for how many Tanzanians are on antiretrovirals vary a lot and are vague; they don't make it clear what percentage on treatment have the virus under control. Quite a lot of people said to be on treatment are lost to follow-up every year. Many die or move to another area, but this also suggests that numbers on treatment are overestimated as some are registered in more than one place. The majority of HIV positive people in Tanzania are not on treatment and a majority of the population have never been tested for HIV. A large number of people who have never been tested are estimated to be HIV positive.I just don't feel convinced that the money is going to be stumped up to test tens of millions, perhaps hundreds of millions of people every year for the foreseeable and to treat tens of millions for several decades to come. But perhaps I'm just a sceptic (or 'skeptic' if you're in the US).Pre-exposure prophylaxis (PrEP) involves putting HIV negative people on antiretroviral drugs (ARV) with the aim of protecting them from HIV infection. read more..

Monday, 19 March 2012

International Women-Human Rights-Usaid

Respecting women’s human rights by telling them about all their HIV risks

(A posting for International Women’s Day, 8 March) For many years, WHO, USAID, UNAIDS, and other international and foreign aid organizations have misinformed women in Africa about risks for HIV. Experts inside and outside these organization have challenged bureaucrats to tell women what they need to know to protect themselves. But to no avail. WHO, USAID, [...] read more..

Antiretroviral Drugs-Clinical Trials-Hiv Epidemics-Perspective-HIV

UNAIDS: Everyone in Africa is at Risk of HIV; so PrEP is Useless?

I've found an uncharacteristically sensible article on PrEP, although it's written from a US perspective. It concludes that "Findings from the randomized clinical trials that PrEP is efficacious should mark the beginning of the policy discussion, not its end."The article also demands proof of desirability and even deliverability of PrEP before the strategy is implemented. The authors note that sustained and effective counseling is a must to ensure proper adherence to the drugs and that the level of counseling required, which makes up a major part of clinical trials, is unlikely to be part of a community implementation.Also noted are the lengths that researchers had to go to in order to retain participants in the iPrEx trial, an aspect of such trials that is rarely mentioned when reports of standing ovations at expensive pharmaceutical sponsored conferences come out. The odds during the iPrEx trial seemed to have been stacked against getting a poor result. And yet the result was pretty unimpressive.The article covers a lot of interesting aspects of PrEP that are rarely mentioned among the post trial hype, such as development of resistance to antiretroviral drugs, increased 'unsafe' sexual behavior among some who think PrEP will give them 100% protection and the sheer cost of such a program that provides drugs for uninfected people when there isn't even enough funding for those who are infected.But the article, perhaps being written from a rich country perspective, doesn't mention how spectacularly unsuccessful we have been in identifying 'core transmitters' of HIV in developing countries. In fact, any group that could be considered to be contributing significantly to HIV epidemics in high prevalence African countries is dwarfed by the percentage of infections that are said to come from 'low risk' groups.In short,if PrEP ever proved itself to be feasible in high prevalence African countries, we wouldn't have the faintest idea where to start.[For more about HIV and risk, see my other blog, HIVinKenya]Pre-exposure prophylaxis (PrEP) involves putting HIV negative people on antiretroviral drugs (ARV) with the aim of protecting them from HIV infection. read more..

Aids Healthcare Foundation-Magic Johnson Foundation-The Premiere Screening-Downtown Los Angeles

The Magic Johnson Foundation and AIDS Healthcare Foundation...

The Magic Johnson Foundation and Aids Healthcare Foundation co-hosted the premiere screening of Espn Films’ The Announcement this past Tuesday, March 6th. This riveting documentary chronicles the untold story of basketball legend Magic Johnson’s triumphant journey living with HIV. The screening at Downtown Los Angeles’s Regal Cinemas was a star-studded event, with Magic’s friends and supporters on hand to share the moment.AHF President Michael Weinstein praised Magic, calling him a hero and an icon in the fight against AIDS: “We applaud the courage and leadership he continues to show in this battle over the years and thank ESPN Films for both pointing a lens at his remarkable life and for allowing AHF and Magic Johnson Foundation the honor of hosting the premiere of The Announcement.”Don’t miss The Announcement this Sunday, March 11th at 9:00 pm Eastern on ESPN! read more..

Saturday, 10 March 2012

Hiv Prevention Trials Network-Immune Response-Viral Evolution-Incidence Rate-Hiv Incidence

HIV Rates For Black Women In Parts Of The US Much Higher Than Previously Estimated

Study results released indicate that the HIV incidence rate for US women living in areas hardest hit by the epidemic is much higher than the overall estimated incidence rate in the US for black adolescent and adult women. The HIV Prevention Trials Network (HPTN) announced results from its HPTN 064 Women's HIV Seroincidence Study (ISIS) which found an HIV incidence of 0.24% in the study cohort of 2,099 women (88% black), a rate that is five fold higher than that estimated for black women overall by the Centers for Disease Control and Prevention (CDC)... read more..


Study Uses Advanced Gene-Sequencing Technologies To Track Viral Evolution Of HIV

Mutations in HIV that develop during the first few weeks of infection may play a critical role in undermining a successful early Immune Response, a finding that reveals the importance of vaccines targeting regions of the virus that are less likely to mutate... read more..