Thursday, 23 August 2012

Neutralizing Antibodies-Protective Immunity-HIV

HIV Protection Without Circulating Blood Antibodies

Biomed Middle East: "New research shows that protective immunity against HIV can be achieved without the presence of virus neutralizing antibodies in the blood. The study, published by Cell Press in the February issue of the journal Immunity, demonstrates that a vaccine which stimulates production of specific anti-HIV antibodies in the vaginal tissue was sufficient to protect monkeys from exposure to live virus. The results may also help to explain why a few individuals who lack anti-HIV antibodies in the blood are able to resist infection, even when they are repeatedly exposed to HIV. ..."We may have been able to recapitulate in a vaccine what a few individuals do naturally." read more..

Saturday, 11 August 2012

Working Mothers Breastfeed-Ghanaian Chronicle-Post Natal Stress-Maternity Leave

Ghana: Post Natal Stress in Tamale

[Ghanaian Chronicle]Tamale -The Chronicle has learned that several female workers in both the public and private sectors in the Tamale Metropolis often lose their jobs after going on maternity leave, following their inability to manage their work and the children at the same time. read more..


Uganda: Can Working Mothers Breastfeed Exclusively?

[New Vision]Breastfeeding, especially when done exclusively for the first six months, helps babies develop immunity against many diseases. Unfortunately, work prevents many mothers from exclusively breastfeeding their babies, writes Agnes Kyotalengerire read more..

Weight Loss Success Stories-Weight Loss Success Story-Motivation To Lose Weight

Do you love a good weight loss success story as much as we do? Check out the bef...

Do you love a good Weight Loss Success story as much as we do? Check out the before and after pics of these big losers: http://ow.ly/cR3Jc
Before & After: Weight Loss Success Stories | Fitbie
Need inspiration and motivation to lose weight? Read weight loss success stories with before and after pictures from Fitbie read more..

Thursday, 9 August 2012

Randomized Controlled Trial-Drug Manufacturers-Sexual Behavior-Drug Trials

PrEP is Win-Win for Big Pharma, Lose-Lose for Ordinary People

When a PrEP trial produces poor results, the reaction is often to point the finger at the patient: they didn't take the drugs regularly, 'adherence' was low, etc. The irony of this is that people thought of as good candidates for PrEP are often those who have not successfully modified their Sexual Behavior, or have shown themselves unwilling to do so. If they will not or can not modify their sexual behavior, why would they be more willing or able to modify their drug taking behavior?
Some drug trial reports parcel up the high achievers and exclude the low and medium achievers and call it a 'sub-study' or something similar. But the point of a randomized controlled trial is to make it clear what kind of result can be expected of people taking part, not what kind of result can be expected if everyone behaved as drug manufacturers would wish them to. Given that people don't behave in real life as they do during drug trials, the results for strategies such as PrEP so far have been somewhat encouraging, but not good enough to roll out the strategy.
Even with PrEP, people are encouraged to engage in safe sex, to limit their number of partners, to use condoms, etc. If they can't or won't do some or all of those things, PrEP will not be very effective; but it may not have any positive impact at all. Those behind the trials and those producing the drugs are anxious to portray the strategy as tested and proven, but it is most definitely not, not yet anyhow. One of the main exponents of the strategy tries to persuade us that PrEP is the way to go, but some of his readers are clearly not convinced. And the opposing case raises additional concerns about PrEP, referring to the strategy as 'grasping at straws'.
In countries where HIV prevalence is very high and transmission is highest among low (sexual) risk groups, those engaging in heterosexual sex with one HIV negative partner, PrEP is not going to be feasible. Those who face the lowest risk, but are paradoxically the highest risk group in Modes of Transmission Surveys, are unlikely to be targeted by a PrEP campaign.
And given that the majority of HIV positive people in need of treatment are still not receiving it due to cost, infrastructure, political and other reasons, it would be odd to offer the same drugs to people who are still HIV negative. It would seem far better to establish what exactly the risks are and address those risks before throwing yet more drugs at the problem. But PrEP is the way to go if you want to sell lots of drugs to healthy people; if that doesn't work, you'll then have lots of sick people to sell even more drugs to.Pre-exposure prophylaxis (PrEP) involves putting HIV negative people on antiretroviral drugs (ARV) with the aim of protecting them from HIV infection. read more..

Wednesday, 8 August 2012

High Resolution Imaging Science Experiment-Morphological Transformations-Integrative Research Program

Shedding new light on how jaws evolve

If you're looking for information on the evolution and function of jaws, a new integrative research program has some answers. Scientists are investigating major adaptive and morphological transformations in the mammalian musculoskeletal system during development and across higher-level groups. read more..


Orbiter images NASA's latest additions to Martian landscape

Late Monday night, an image from the High Resolution Imaging Science Experiment (HiRISE) camera aboard Nasa's Mars Reconnaissance Orbiter captured the Curiosity rover and the components that helped it survive its seven-minute ordeal from space to its present location in Mars' Gale Crater. read more..


Planting the seeds of defense: Stress triggers widespread epigenetic changes that aid in disease resistance

It was long thought that methylation, a crucial part of normal organism development, was a static modification of DNA that could not be altered by environmental conditions. New findings, however, suggest that the DNA of organisms exposed to Stress undergo changes in DNA methylation patterns that alter how genes are regulated. read more..

Canadian Medical Association Journal-University Of British Columbia-Learning Disability

Against The Odds: Overcoming A Learning Disability Will Make A Physician-In-Training A Better Doctor

Overcoming a learning disability to become a Physician will actually help in being compassionate toward patients, writes a Medical Student of his struggle with a severe reading disability in CMAJ (Canadian Medical Association Journal). Daniel Heffner, a medical student at the University Of British Columbia who will graduate in 2013, has struggled with a severe reading disability that caused laborious reading and poor marks in school until he was diagnosed at age 12. His diagnosis allowed him to realize he could succeed, and he applied himself to overcoming his disability... read more..

Friday, 20 July 2012

Transmission Of Hiv-Male Circumcision-HIV

Get Circumcised or Get Labeled

My first big shock when I started to follow HIV related issues in East Africa was that it was assumed almost all Transmission was sexual in Africa (though nowhere else). Then, to 'work out' how this could possibly generate such massive epidemics, there was also the tendency to go from the number infected, or said to be infected, to the absurdly high levels of unsafe sexual behavior that would be needed to explain high levels of heterosexual transmission of HIV. There has never been any evidence that unsafe heterosexual sex alone could explain Africa's worst HIV epidemics. But all the 'work' to prevent infection appeared to concentrate on sexual transmission.
If not all HIV is transmitted sexually, many interventions that target sexual behavior, whether levels are real or assumed, will fail. Abstinence and other associated campaigns didn't even sound plausible before they were implemented, but enormous amounts of money was ploughed into them. Some equally dubious interventions were dreamed up and most probably also had little positive effect; as for any negative effects, these are unlikely to have been measured, let alone alluded to in the copious self-congratulatory literature that has emerged from what became the extremely lucrative HIV industry.
When circumcision was mooted as a possible intervention, it seemed to suffer from the above problem; it would, at best, protect against heterosexual transmission; it would not protect men who have sex with men, infants who are infected by their mothers or intravenous drug users. Indeed, it turned out that it wouldn't protect women either, and probably increases transmission from men to women. It will not reduce non-sexual transmission of any kind, including that through unsafe healthcare or cosmetic practices. Worse, in the sub-standard health facilities that ordinary Africans are forced to use, mass male circumcision programs might add to the problem, with men being infected in the health facility where the operation is carried out.
But those receiving circumcision related funding continue to insist on the effectiveness of such programs, shouting down any opposition, churning out figures which could be interpreted to show that male circumcision reduce transmission from women to men, but never actually engaging with the opposition. There are now so many problems with male circumcision as a strategy that the whole exercise to circumcise between 22 and 38 million African men should be suspended. There is so much disinformation and consequent misunderstanding that the campaign is unlikely to do any good and is in serious danger of doing a lot of harm. At best, it is just another neo-colonial excess of the kind that probably ensured that HIV would become the pandemic that it now is.
Kenya's Nairobi Star is currently doing a great job adding to the obfuscation that seems to pass for scientific journalism. The article 'Study Claiming Cut Does Not Inhibit HIV Rejected' makes a shaky start by incorrectly suggesting the study was not published or that its findings were refuted, or were even addressed by those promoting circumcision. The cited claims from the study are, in fact, correct, but they are only the tip of the iceberg. Interviewing those who would have a lot to lose if the circumcision program was suspended and asking their opinion is easy enough. But is it adequate journalism? Does the public really need more of the selective use of factoids to justify spending hundreds of millions of dollars on a campaign that is likely to be of so little benefit (at best)?
Other countries have less to say about the latest paper, one of several that has managed to get through the HIV industry's censorship process (peer review). Uganda's press has commented on circumcision from time to time, but only to beat the orthodox drum. It is claimed that 600,000 men have already been circumcised under the program since 2009, but it is unclear where this figure comes from. Natu read more..